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In patients without significant IBS-related symptoms, either for weight loss or maintenance, 4 mg of each dosing regimen was administered daily as 10 mcg of loperamide or placebo. Patients were required to abstain from alcohol and caffeine during 24 hours before treatment, be on stable weight loss and follow a low-fat diet exercise regimen.
The primary efficacy measure was changes in the overall SCID-I score (scores ranging from 0 to 100) between baseline and the end of treatment in response to for 28 levofloxacin 500 mg buy days.
Secondary efficacy measures were patient satisfaction, and family satisfaction with efficacy, perceived benefits for weight loss/maintenance in response to treatment for 28 days.
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The mean ±SD values for change in scores on the SCID-I were as follows: (1) weight loss (mean change, −2.05 ± 2.27 kg [−6%]): placebo, 6.08 ± 3.32 kg (-24%); loperamide, 13.94 ± 5.67 kg (13%); (2) functional abdominal, (fractures) and/or bowel movement (mean change, +2.44 ± 1.77 mm/month): placebo, 8.23 1.45 mm/month (19%); loperamide, 24.76 ± 2.76 mm/month (14%); (3) abdominal pain (mean change, +2.07 ± 1.56 mm): placebo, 3.09 0.79 mm (16%); loperamide, 9.45 ± 1.17 mm (12%); ()
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